02-05-2016, 12:47 PM
The following excerpts are from abstracts from two scientific papers published by the National Institute of Health, that indicate that increased levels of the amino acid leucine, which meat and dairy foods supply in high amounts, can accelerate aging (reduce lifespan) by a molecular mechanism called “TOR Signaling,” as well as increase the likelihood of developing adult onset (type 2) diabetes and obesity. Please especially note the emphasized passages:
Quote:Leucine signaling in the pathogenesis of type 2 diabetes and obesity
Epidemiological evidence points to INCREASED DAIRY AND MEAT CONSUMPTION, staples of the Western diet, as MAJOR RISK FACTORS FOR THE DEVELOPMENT OF TYPE 2 DIABETES (T2D). This paper presents a new concept and comprehensive review of LEUCINE-mediated cell signaling explaining the pathogenesis of T2D and obesity by leucine-induced over-stimulation of mammalian target of rapamycin complex 1 (mTORC1).
DAIRY PROTEINS AND MEAT stimulate insulin/insulin-like growth factor 1 signaling and PROVIDE HIGH AMOUNTS OF LEUCINE, a primary and independent stimulator for mTORC1 activation….Plant-derived polyphenols and flavonoids are identified as natural inhibitors of mTORC1 and exert anti-diabetic and anti-obesity effects…. ATTENUATION OF leucine-mediated mTORC1 signaling by defining appropriate upper limits of the daily intake of LEUCINE-RICH ANIMAL AND DAIRY PROTEINS may offer a great chance for the prevention of T2D and obesity, as well as other epidemic diseases of civilization with increased mTORC1 signaling, especially cancer and neurodegenerative diseases, which are frequently associated with T2D.
Quote:TOR signaling never gets old: Aging, longevity and TORC1 activity
The TOR (target of rapamycin) signal transduction network monitors intra- and extracellular conditions that favor cell growth. Research during the last decade has revealed a modular structure of the TOR signaling network. Each signaling module senses a particular set of signals from the cellular milieu and exerts regulatory control towards TOR activity. The TOR pathway responds to growth factor signals, nutrient availability, and cellular stresses like hypoxia and energy stress. The signaling modules and their molecular components constituting the TOR network are remarkably conserved in both sequence and function across species. In yeast, roundworms, flies, and mice, THE TOR PATHWAY HAS BEEN SHOWN TO REGULATE LIFESPAN. Correspondingly, genetic, dietary or pharmacological manipulation of individual signaling modules as well as TOR activity itself EXTENDS LIFESPAN in these model organisms. We discuss the potential impact of manipulating TOR activity for human health and lifespan.